Organizing my Life!

I long to be organized! I have five children and a full time job and I suffer from an illness which is most debilitating. I am often unable to complete simple tasks! Husband and family help out when they can. I have a problem in allocating a home for everything, and there isn't that much clutter around my home. It's all out of sight. My home is clean and appears tidy. I can't seem to maintain everything in an organized state for long. I can feel totally overwhelmed by the disorganization and frequently spend a good deal of time looking for things. How can I reclaim my organized home? I seem to have no time!